Shanghai's public health authorities confirmed a human H7N9 case Friday.
The male patient, 59, is a Shanghai resident, said the Shanghai Municipal Health and Family Planning Commission.
The patient is receiving treatment in hospital, the commission said.
H7N9 is a bird flu strain first reported to have infected humans in March 2013 in China. It is most likely to strike in winter and spring.
Last winter, human cases of H7N9 were reported in several Chinese provinces and municipalities, including Guangdong, Shanghai, Fujian, Jiangxi, Guizhou and Zhejiang.
Health specialists advised that people steer clear of live poultry to reduce infection risks.
