He grew up in a small village with poor educational opportunities. His father, who didn't finish high school and was locked out of many work opportunities in big cities because of it, impressed upon He and his younger brother from their boyhood the importance of studying hard, using his own experience as an example.
"My father was always strict with us so we'd avoid repeating his experience," He said.
Unlike his father, He's mother was more like a friend, who always encouraged him through the challenges of learning and life. "One of the biggest problems for rural students is that the available educational resources are limited and students lack motivation," He said. "So thanks go to my dad for pushing me to study in that environment and to my mom, whose encouragement helped keep me focused on my studies."
He graduated from the University of Science and Technology of China — one of China's top universities — with a bachelor's degree in 2009 and was accepted into Harvard's PhD program on full scholarship the same year. All he knew about America was from books and films and he was in for some culture shock.
"Studying at Harvard, everybody around me was outstanding and my English was not as fluent as it is now. I lost confidence. I even began to wonder how I ever got accepted to Harvard," he said.
But with time he found his footing.
"The thing I like about American campus culture is that it's diversified and encourages diversity," he said. "As long as you are willing to discover, you can find a variety of resources you are interested in, to communicate with professionals and to make friends."
He took a job as resident tutor for undergraduates and through that he learned about the commencement orations competition.
Apart from working and studying, He took part in activities both on and off campus, including start-up and innovation sharing sessions, activities held by Chinese student associations and reading clubs.
"I've always had a great interest in literature," He said.
One of his favorite authors is Peter Hessler. "His books River Town, Oracle Bones and Country Driving are all my favorites," he said.
Encouraged by a history professor, He took up a pen and started writing about rural China in English.
"China has been undergoing such rapid development in recent years and China's villages have developed rapidly as well. Foreigners have more knowledge of China's mega cities, but with a limited number of channels, their impressions of China's rural life may still be lacking," said He, who has deep feelings for his hometown and still goes back to visit.
"I hope more of China's voices will be heard in the West, since what we have done so far is far from enough," He said
Taking advantage of weekends and spare time, He finished up his book and just signed with one of Europe's biggest publishers.
He has already begun work as a postdoctoral fellow at MIT's Koch Institute for Integrative Cancer Research, where he will study malaria and hepatitis virus infection, and ultrasensitive early cancer diagnostics.
It hasn't been an easy road, but that's okay. "Perhaps it's because I suffered a lot growing up, so many frustrations to me are things I can definitely bear," He said.