Despite some elements of competition, Wang said that China-U.S. ties were defined more by partnership than rivalry.
He also noted the steady improvement in China-Japan relations, calling for mutual trust with India, and saying that the "sky is the limit" for China-Russia cooperation.
There is a hard-won tranquility in the South China Sea. China has strong resolve and deep commitment to maintain peace and stability there, Wang said.
The de-stabilizing factor, Wang noted, comes from outside the region with frequent show of force with fully-armed aircraft and naval vessels.
He said after the "China collapse theory" collapsed, various forms of "China threat theory" were now losing steam.
HELPING AND SHARING
China's major-country diplomacy is not about dealing only with the developed and the powerful. China is still the world's largest developing country, and it stands up for the weak and small, playing a constructive role in solving regional problems.
Wang pointed out that China today was in a much better position to help resolve various regional and international issues.
On the Korean Peninsula, China's suspension-for-suspension proposal has proven the best way to create the basic conditions for improving the peninsula situation.
Last year, China proposed a three-phase solution to help settle the issue in Myanmar's Rakhine state. Beijing also held a Palestine-Israel peace symposium and a meeting to improve Afghanistan-Pakistan relations.
He said Beijing would respect the wishes and sovereignty of other countries, not meddle in their affairs, nor impose its views on others.
China's major country diplomacy is also about helping the least developed.
Even as it has rapidly developed, China remains a good brother and partner of Africa.
"Africa's concerns are China's concerns. Africa's priorities are China's priorities," Wang said, adding that African countries are welcomed to board China's fast train of development.
This year, a focus of the FOCAC summit will be sharing the opportunities presented by the Belt and Road Initiative.
Into its fifth year, the initiative aims to benefit the world using trade and infrastructure cooperation. More than 80 countries and organizations have signed deals with China.
Wang said the initiative was a transparent one that followed the "golden rule" of extensive consultation, joint contribution and shared benefits.
"Everything is in the open. There are no backroom deals and every step is transparent," Wang said.
China had been a strong advocate of trade liberalization.
"The more China develops, the more it can contribute to the world," he said.
Envisioning a community of shared future for humanity, Xi has said China is committed to building an open, inclusive, clean and beautiful world that enjoys lasting peace, universal security and common prosperity.
William Jones, Washington Bureau chief of the U.S. publication Executive Intelligence Review, said Xi's proposal is an attempt to overcome and replace the traditional notion of "geopolitics", in which there are always "winners" and "losers", and in which the principle of "might makes right" tends to predominate.
"In this new concept, everyone plays a role and the benefits achieved by any one nation can be shared by all," Jones added.