The United States collected DNA from all over the world to study the mortality rate of the elderly population

2020-04-28 Ecns.cn Editor:Gu Liping

The United States collected DNA from all over the world to study the mortality rate of the elderly population

By Tong Zeng

(About the author: Tong Zeng, Master of law, Peking University. After the outbreak of SARS in 2003, he wrote and published a book called “Last Line of Defense” (Anxiety about the Chinese gene loss). For the past 30 years Tong Zeng has been seeking compensation for the Chinese war victims of World War II, and he has been nominated for the Nobel Peace Prize multiple times. )

With the recent development and outbreak of COVID-19, I have noticed that elderly people in particular are very susceptible to this virus, especially those with underlying diseases, and the death rate of these elderly infected patients is very high. The joint Expert Study Group of China and the World Health Organization (WHO) recently held a press conference in Beijing, in which they stated: middle-aged and elderly people are at higher risk of being infected with COVID-19. Looking at the entire patient population it is easy to see that the death rate of people over 65 years old is higher. The average age of the deceased in Italy is over 80 years old, and some towns have lost almost all of their elderly population. The early death rate of COVID-19 in South Korea is close to 1% and 90% of those are people over 60 years old. In the United States, most of the deceased are between 70 and 90 years old. French Director General of Health Jerome Salomon has also stated that 93% of the deceased from COVID-19 in France are over 65 years old.

17 years ago the deadly SARS virus mainly attacked the respiratory system of humans, where only the lungs were affected and not the whole immune system, whereas this new COVID-19 virus is able to target the cardiovascular system, respiratory system, immune system, digestive system, as well as pre-existing medical conditions, and therefore accelerate the death of the elderly who are infected with it. This reminded me of an international project of American organizations, that started over 20 years ago. It was called “Model and Analysis of Mortality Rate of the Elderly”.

The United States has been collecting DNA globally to form a “Mortality Model for the Elderly”

In the 1990’s, when the concept of human genetic resources was not yet clear to people all over the world, the United States started massive global collections and research of human DNA in Asia, Africa and Europe. It was called the epoch-making Human Genome Project. One of the programs was “Model and Analysis of Mortality Rate of the Elderly”, in which the diseases afflicting the elderly were researched. They specifically listed hypertension, diabetes, heart disease, epilepsy and other cerebrovascular diseases, bronchitis, emphysema, asthma and pneumonia, tuberculosis, and several others, as the 18 most common diseases among the elderly. In order to research these basic diseases, it was necessary to collect their DNA by taking blood samples. This was funded by the National Institutes of Health (NIH) in the United States. In 1996, the Duke University of the United States separately signed contracts with the Max Planck Institute of Germany and Odense University of Denmark to facilitate the collection of blood samples from the elderly populations of SouthCentral and Northern Europe. Another American organization, in cooperation with research institutions in Saudi Arabia and other countries, also collected blood samples from elderly Middle Eastern populations. 

Also, at that time, a Chinese scholar who had studied in the United States signed a subcontract with the Odense University of Denmark. The scholar was tasked with collecting blood samples from about 300 elderly Chinese citizens in Beijing, Hangzhou and Chengdu, which were then to be sent on to the United States. At the end of 1997, he also reached a separate agreement with the Duke University in the United States, involving a joint project to collect blood samples of tens of thousands elderly Chinese. Excluding five provinces and regions in Northwest China with more ethnic minorities, and Tibet, Inner Mongolia, Yunnan and Hainan, the project covered 22 provinces, regions and municipalities and about 100 million elderly Chinese. In order to obtain the approval of domestic aged care offices, he changed the name of the project from “Model and Analysis of Mortality Rate of the Elderly” to “Longevity and Health Monitoring of the Elderly in China”. The Chinese translation of the English contract avoided the words DNA and claimed that the purpose of collecting blood samples from the elderly Chinese was to monitor their health. At that time, I was working at one of the aged care offices and was hoping that I could stay in Beijing and participate in this international project. But the project manager told me that Beijing, Guangdong, Hubei, Shanghai and Heilongjiang were the 5 most important locations and required more professional staff to be in charge. So, I was sent to Hebei province, the nearest project location from Beijing and was responsible for the work in that area, including collecting blood samples.

Geneticist Bent Petersen, from the Odense University of Denmark, demonstrated the blood samples. Tong Zeng is on the lower right. Picture provided by Tong Zeng

On the March 4, 1998, I attended a training meeting for Chinese investigators at the Tibet Hotel in Beijing. Geneticist Bent Petersen, from the Odense University of Denmark, shared his experience on collecting blood samples in Northern Europe and requested the Chinese investigators follow his protocol. The specific method is to soak the elderly person’s hand in hot water for a period of time, then rub the hand to heat it up even more, then insert a needle from the side (either side) of the finger. The finger will start to bleed (the first drop of blood shouldn’t be used) and starting from the second drop, the blood should be dripped onto 5 circles of filter paper. According to the tests, it takes at least 2 drops to fill up one circle. If blood from one finger is not enough, the other finger will be used. This means that at least 11 drops of blood should be taken from one person, and it takes more than one minute to accomplish. The use of iodine is strictly prohibited.

At that time, I was against this kind of blood collection because most of the targeted people, aside from being elderly, were also often weak and thin and this kind of blood collection would have been harmful and torturous to them. Later, I gradually discovered that the project was doing genetic research and collecting DNA. After I made this public, dozens of domestic media immediately supported me with a large number of reports. Many foreign media, such as AFP (Agence France-Presse), Reuters and American “Science” magazine also participated in the reports. Due to the pressure of public opinion, the collected blood samples could not be sent to the United States and were seized at a university in China. The Chinese scholar who studied in the United States has since changed the name of the project and found another department. After the year 2000, he continued to cooperate with the United States. He even contacted some hospitals in China and asked them to repeatedly collect blood samples of the elderly in 22 provinces, regions and municipalities. Thousands of blood samples were then sent to US laboratories in batches. He also gave the United States data on the overall basic diseases of the elderly in China.

Whilst samples were given to the Duke University in the United States, it is quite possible that they have also provided the research results of those elderly people’s DNA to other laboratories in the United States, because the subcontract signed by Duke University and the Chinese scholar clearly stated that the National Institutes of Health (NIH) subcontract the blood collection project to a population research institute in China through Duke University. The University provides the funds to the Chinese subcontractor. The contract clearly stipulates that Duke University can require the subcontractor to change the work content an unlimited amount of times. Under the premise of non-exclusive possession, the copyright allows the U.S. government to copy, translate, publish, use and transfer it, and grant equal rights to other U.S. agencies. The contract shall be interpreted according to the laws of North Carolina.

Also, in the process of blood collection in China, a questionnaire survey was added. For example, as part of the questionnaire in the year 2000, they investigated the longitude and latitude of the towns where the elderly lived, the average temperature in January and July of each year, the number of frost free days in a year and the statistical data of average rainfall over a period of many years, as well as the land type and the main food structure of the elderly's place of residence. In another booklet, there were projects to investigate the survival rate of the elderly that had given blood in 1998, to determine which of them had died and whether they had died naturally, or from a disease, with special emphasis on the time of death. It was also required to provide proof of these facts from a third party. All of the data listed above was given to the United States without reservation. 

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