Two Israeli missiles landed near the international airport of Damascus after midnight Tuesday, Syrian state TV reported.
The state TV spelled no further details, but activists on the ground who reported the sound of explosion minutes ahead of the TV report said the Israeli missiles left a "medium" explosion.
The precise target of the fresh Israeli attack is still unknown.
Israel has repeatedly targeted military positions in Syria, including the airport of Damascus, on the pretext that it was targeting Iranian forces based in Syrian military sites.
In May, Israel targeted several Syrian military positions, claiming that it was targeting Iranian bases in Syria.
On Sunday, Israel struck positions of pro-government Shiite fighters near the Syrian-Iraqi border, killing over 40 of them.
The Syrian government has accused Israel of supporting the "terrorist groups" in Syria, saying that attacks have been launched in their favors.
The Israeli side has made it clear that they won't tolerate any Iranian presence in Syria. It is escalating strikes against Syrian bases, which Israel claims are hosting Iranian fighters. (Updated)
