Second seed Li Na was upset by Russia's Elena Vesnina in the quarterfinals of the Eastbourne International tennis tournament on Thursday.
The world No 6 and former French Open champion lost 7-6 (7-4), 6-3 to Vesnina, ranked 36th in the world, in one hour and 40 minutes.
In the other matches, Fernando Lopez beat Fernando Verdasco 6-4, 7-6 (8-6) in an all-Spanish affair.
Lopez will next take on Ivan Dodig of Croatia, who defeated eighth seed Fabio Fognini 6-3, 6-2.
American Jamie Hampton reached the semifinals with a 3-6, 7-6 ( 7-1), 6-4 victory over Czech Republic's Lucie Safarova.
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