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Special drug tricks the body into feeling full (2)

2015-01-07 16:57 China Daily Web Editor: Yao Lan
1

Obesity has reached epidemic proportions globally, with at least 2.8 million people dying each year as a result of being overweight or obese, according to the World Health Organisation.

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It warns 44 per cent of the diabetes burden, 23 per cent of the heart disease burden and between 7 per cent and 41 per cent of the burden of certain cancers are attributable to people being overweight or obese.

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And with just one diet drug on the market, growing numbers of people are restoring to going under the surgeon's knife.

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The excitement surrounds a new medicine called fexaramine.

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Given to obese mice fed fatty food, it stopped them from piling on the pounds.

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Fat was burnt off, levels of artery-clogging cholesterol fell and blood sugar levels were better controlled.

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The drug also sped up metabolism and turned harmful white fat that wobbles around the waist into healthy brown fat.

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Remarkably, it did all this without affecting appetite.

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If the drug worked as well in people, it might mean could keep their weight under control while eating just as much as usual.

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They may even be able to keep trim while feasting on chips, cakes and other fatty foods.

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Professor Evans, of the Salk Institute in California, said that fexaramine works by making the body believe it has eaten a big meal.

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When the drug hits the stomach, it kick-starts digestion.

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Fexaramine also spurs the body into burning off fat to create space to store the incoming nutrients.

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The medicine doesn't pass into the bloodstream and circulate round the body but stays in the stomach, which should cut the risk of side-effects.

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